RESUMO
INTRODUCTION: Acute tonsillopharyngitis (ATP) is a very common disease in children. In non-streptococcal ATP, systemic antibiotics are usually not indicated, but topical antimicrobial therapy is advisable. OBJECTIVE: To evaluate the effectiveness of the combination of cetylpyridinium chloride with gramicidin C in the form of a spray in children with ATP in a prospective multicenter non-interventional study.Patients and methods. The study included 94 patients aged 6-15 years with non-streptococcal ATP. A standard examination, assessment of the pain intensity in the throat using a visual analogue scale, assessment of the pain frequency during swallowing and a score assessment of objective manifestations were carried out. Sixty-eight patients of the main group received a combination of cetylpyridinium chloride with gramicidin C (Grammidin for children) in the form of a spray, 26 patients of the control group received throat irrigation with saline solution (based on sea water) for 7 days. Therapy was assessed after 1 day (by phone), 4 and 8 days (by examination). RESULTS: The groups of patients did not differ significantly in terms of demographic indicators and initial clinical manifestations. Body temperature initially did not differ, but was significantly lower in the main group after 1 (p=0.003) and 4 (p=0.04) days. The sore throat pain intensity decrease in the main group significantly exceeded this indicator in the control group after 1 (p<0.001) and 4 (p <0.001) days. Initially, swallowing pain was observed in all patients, after 4 days the complaint was significantly less frequent in the main group (p<0.001). The total assessment of objective data was significantly lower in the main group after 4 (p<0.001) and 8 (p<0.001) days. No adverse effects of pharmacotherapy were observed. CONCLUSIONS: The study showed high efficacy and safety of the cetylpyridinium chloride and gramicidin C (in the form of a spray) combination for non-streptococcal ATP in children aged 6-15 years.
Assuntos
Preparações Farmacêuticas , Faringite , Infecções Estreptocócicas , Adolescente , Antibacterianos , Criança , Humanos , Faringite/diagnóstico , Faringite/tratamento farmacológico , Estudos Prospectivos , Streptococcus pyogenes , Resultado do TratamentoAssuntos
Cirurgia Geral , Análise e Desempenho de Tarefas , Competência Clínica/normas , Competência Clínica/estatística & dados numéricos , Cirurgia Geral/normas , Cirurgia Geral/estatística & dados numéricos , Humanos , Controle de Qualidade , Federação Russa , Centro Cirúrgico Hospitalar/normas , Centro Cirúrgico Hospitalar/estatística & dados numéricos , Recursos HumanosRESUMO
Lipid peroxidation (LPO) and antioxidant system (AOS) were examined in 40 inpatients with chronic obstructive bronchitis (COB) on conventional treatment. The above parameters were considered in relation to clinical picture. It is shown that inflammation in the bronchial tree is associated with AOS functional deterioration and marked LPO intensification. A correlation was established between LPO activity, concentration of alpha-tocopherol in red cell membrane and degree of bronchial obstruction as well as remission quality. Persistent high intensity of LPO is suggested as an underlying cause of the disease transition to chronic form and progression of bronchial obstruction. Basing on the above observations, the authors insist on antioxidants introduction in COB treatment.
Assuntos
Bronquite/etiologia , Adolescente , Adulto , Antioxidantes , Bronquite/sangue , Bronquite/fisiopatologia , Bronquite/terapia , Doença Crônica , Progressão da Doença , Hospitalização , Humanos , Peroxidação de Lipídeos , Pessoa de Meia-Idade , Recidiva , Respiração , Fatores de TempoRESUMO
The physico-chemical properties of preparation MIGI-K from mussels are given. Some characteristics of melanoidin fractions of MIGI-K are presented, their similarity to standard melanoidin is revealed. The given data on biological activity of the preparation permit to consider MIGI-K as immunomodulator.
Assuntos
Adjuvantes Imunológicos/química , Bivalves , Polímeros/química , Hidrolisados de Proteína , Adjuvantes Imunológicos/análise , Aminas/análise , Aminoácidos/análise , Animais , Fenômenos Químicos , Físico-Química , Dipeptídeos/análise , Ácidos Graxos não Esterificados/análise , Polímeros/análise , Espectrofotometria Infravermelho , Oligoelementos/análiseAssuntos
Abscesso/cirurgia , Apendicite/cirurgia , Sucção/métodos , Abscesso/etiologia , Doença Aguda , Adulto , Idoso , Idoso de 80 Anos ou mais , Apendicectomia , Apendicite/complicações , Celulite (Flegmão)/etiologia , Celulite (Flegmão)/cirurgia , Feminino , Humanos , Perfuração Intestinal/etiologia , Perfuração Intestinal/cirurgia , Pessoa de Meia-Idade , Peritonite/etiologia , Peritonite/cirurgia , Poliuretanos , Ruptura Espontânea , Sucção/instrumentaçãoAssuntos
Neoplasias dos Genitais Femininos/complicações , Neoplasias Intestinais/complicações , Obstrução Intestinal/cirurgia , Neoplasias da Bexiga Urinária/complicações , Adulto , Idoso , Constrição Patológica , Feminino , Humanos , Obstrução Intestinal/etiologia , Masculino , Pessoa de Meia-IdadeRESUMO
The authors describe the most frequent complications of gastrostomy (incompetent gastrostomies, purulent inflammation of the wound, disturbed evacuatory function of the stomach etc.). Their causes, ways of prevention and elimination are analyzed.